A Bilayered Poly (Lactic-Co-Glycolic Acid) Scaffold Provides Differential Cues for the Differentiation of Dental Pulp Stem Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29984629.
- Also identified by DOI 10.1089/ten.TEA.2018.0041.
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Abstract
In this article we used an FDA-approved biodegradable biomaterial, poly (lactic-co-glycolic acid) (PLGA 75:25) to generate a bilayered scaffold with the capacity to induce differential, layer-specific dentinogenic differentiation of dental pulp stem cells (DPSCs) in vitro. We surmise that such a scaffold can be used in conjunction with current regenerative endodontic procedures to help regenerating a physiologic dentin-pulp complex in vivo. We hypothesize that our scaffold in conjunction with DPSCs will advance current regenerative endodontics by restoring dentin and initiating the innervation and revascularization of the pulp.
Medical subject headings
- Biocompatible Materials
- Cell Differentiation
- Dental Pulp
- Dentin
- Polylactic Acid-Polyglycolic Acid Copolymer
- Stem Cells
- Tissue Scaffolds