Gut microbiota associations with common diseases and prescription medications in a population-based cohort.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 29985401.
- Also identified by DOI 10.1038/s41467-018-05184-7 and PMC identifier 6037668.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.
Medical subject headings
- Disease
- Feces
- Gastrointestinal Microbiome
- Gastrointestinal Tract