Near-infrared light-triggered drug delivery system based on black phosphorus for in vivo bone regeneration.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 29986234.
- Also identified by DOI 10.1016/j.biomaterials.2018.06.039.
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Abstract
A near-infrared (NIR) light-triggered drug delivery platform is produced by incorporating SrCl<sub>2</sub> and BP nanosheets (BPs) into poly(lactic-co-glycolic acid) (PLGA) for bone regeneration. The fabricated BP-SrCl<sub>2</sub>/PLGA microspheres show efficient NIR absorption and photothermal effects due to the BPs. The NIR-triggered release behavior of Sr<sup>2+</sup> by flawing the PLGA shells is investigated and the microspheres exhibit excellent cell viability and biodegradability. Implantation of the BP-SrCl<sub>2</sub>/PLGA microspheres into a rat femoral defect demonstrates good tissue compatibility and excellent bone regeneration capacity under NIR light irradiation. Our study indicates that local release of Sr<sup>2+</sup> at optimal time periods controlled by NIR irradiation improves bone regeneration significantly and this NIR-triggered drug delivery system composed of BPs is suitable for therapies requiring precise control at specific time.
Medical subject headings
- Phosphorus