Tailoring the mechanical property and cell-biological response of β-tricalcium phosphate composite bioceramics by SrO-P<sub>2</sub>O<sub>5</sub>-Na<sub>2</sub>O based additive.
basic_science · Level V
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- Record sourced from PubMed, PMID 29986296.
- Also identified by DOI 10.1016/j.jmbbm.2018.06.036.
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Abstract
β-tricalcium phosphate (β-TCP) bioceramic, which is a prevalent bone graft, is deficient in mechanical strength and mediating the biological functions. In the present study, β-tricalcium phosphate composite bioceramics (TCP/SPNs) were prepared by introducing SrO-P<sub>2</sub>O<sub>5</sub>-Na<sub>2</sub>O based (SPN) sintering additive. With increasing mole ratio of SrO to P<sub>2</sub>O<sub>5</sub>, the SPN tended to crystallize. In the liquid-phase sintering process, β-TCP reacted with SPN, producing new compounds. The difference in characteristic of SPN additive affected the compressive strength and cell-biological response of the fabricated TCP/SPNs. By selecting SPN with appropriate formulation, the TCP/SPNs not only could more than double their compressive strength, but also improved the cell viability, promoted osteogenic differentiation and inhibited osteoclastic activities. Taken together, this work establishes a beneficial strategy to improve the overall performance of calcium phosphate bioceramic for application in bone regeneration.
Medical subject headings
- Biocompatible Materials
- Calcium Phosphates
- Ceramics
- Mechanical Phenomena
- Oxides
- Phosphorus Compounds
- Sodium Compounds