Noninvasive Treatment-Efficacy Evaluation for HIFU Therapy Based on Magneto-Acousto-Electrical Tomography.

Abstract

OBJECTIVE: As a novel noninvasive modality of oncotherapy or stroke treatment, high-intensity focused ultrasound (HIFU) has drawn more and more attention in the past decades. Whereas, real-time temperature monitoring and treatment-efficacy evaluation are still the key issues for HIFU therapy. METHODS: Based on the temperature-conductivity relation of tissues with a sharp conductivity variation of irreversible thermocoagulation at 69 °C, a noninvasive method of treatment-efficacy evaluation for HIFU ablation using the magneto-acousto-electrical tomography (MAET) technology is theoretically studied. By applying the nonlinear Khokhlov-Zabolotskaya-Kuznetsov equation and Pennes equation, a cylindrical model is established to simulate the distributions of pressure, temperature, and conductivity with the consideration of harmonic components. RESULTS: The MAET signals are simulated to analyze the characteristics of the peak amplitude and the axial interval of the two clusters generated by the conductivity boundary of HIFU ablation. CONCLUSION: The axial interval can be used as the indictor to evaluate the size of HIFU ablation with the minimum axial width of one wavelength. SIGNIFICANCE: The favorable results demonstrate the feasibility of real-time treatment-efficacy evaluation for HIFU therapy using the MAET technology and suggest potential applications in clinical practice.