A hierarchical Bayesian model to predict APOE4 genotype and the age of Alzheimer's disease onset.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 30001420.
- Also identified by DOI 10.1371/journal.pone.0200263 and PMC identifier 6042730.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this work we use a hierarchical Bayesian paradigm to introduce a theoretical framework to determine an individual's Apolipoprotein ε4 (APOE4) genotype, which heavily influences both the age of onset and probability of acquiring Alzheimer's disease (AD). This calculation is based solely on an individual's family history. This APOE4 genotype estimation is then combined with a number of known factors that influence AD onset to produce a function that estimates the onset of AD as a function of age. We disseminated our Alzheimer's predictive tool online at http://www.alzheimerspredictor.com.
Medical subject headings
- Alzheimer Disease
- Apolipoprotein E4