Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 30002074.
- Also identified by DOI 10.1136/bmj.k601 and PMC identifier 6041728.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mendelian randomisation uses genetic variation as a natural experiment to investigate the causal relations between potentially modifiable risk factors and health outcomes in observational data. As with all epidemiological approaches, findings from Mendelian randomisation studies depend on specific assumptions. We provide explanations of the information typically reported in Mendelian randomisation studies that can be used to assess the plausibility of these assumptions and guidance on how to interpret findings from Mendelian randomisation studies in the context of other sources of evidence
Medical subject headings
- Causality
- Confounding Factors, Epidemiologic
- Effect Modifier, Epidemiologic
- Genome-Wide Association Study
- Mendelian Randomization Analysis
- Observational Studies as Topic