Ratiometric nanothermometer in vivo based on triplet sensitized upconversion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30002372.
- Also identified by DOI 10.1038/s41467-018-05160-1 and PMC identifier 6043590.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Temperature is an essential factor that counts for living systems where complicated vital activities are usually temperature dependent. In vivo temperature mapping based on non-contact optical approach will be beneficial for revealing the physiological phenomena behind with minimized influence to the organism. Herein, a highly thermal-sensitive upconversion system based on triplet-triplet annihilation (TTA) mechanism is pioneered to indicate body temperature variation sensitively over the physiological temperature range. The temperature-insensitive NaYF<sub>4</sub>: Nd nanophosphors with NIR emission was incorporated into the temperature-responsive TTA-upconversion system to serve as an internal calibration unit. Consequently, a ratiometric thermometer capable of accurately monitoring the temperature changes in vivo was developed with high thermal sensitivity (~7.1% K<sup>-1</sup>) and resolution (~0.1 K).
Medical subject headings
- Fluorides
- Metal Nanoparticles
- Neodymium
- Thermometers
- Thermometry
- Yttrium