Cryo-EM structure of the polycystin 2-l1 ion channel.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30004384.
- Also identified by DOI 10.7554/eLife.36931 and PMC identifier 6056229.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.
Medical subject headings
- Calcium Channels
- Cryoelectron Microscopy
- Receptors, Cell Surface