The Tuft Cell-ILC2 Circuit Integrates Intestinal Defense and Homeostasis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30007413.
- Also identified by DOI 10.1016/j.cell.2018.06.037.
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Abstract
The intestinal response to helminth infection is mediated by a recently established type 2 immune circuit that consists of intestinal tuft cells and type 2 innate lymphoid cells (ILC2s). Schneider et al. have discovered that tuft cells sense succinate fermented by Tritrichomonas via GPR91 to drive the IL-25-ILC2-IL-13-dependent immune circuit and intestinal remodeling.
Medical subject headings
- Immunity, Innate
- Intestine, Small