Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37.
Where this comes from
- Record sourced from PubMed, PMID 30010628.
- Also identified by DOI 10.1172/JCI122203 and PMC identifier 6063497.
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Abstract
Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.
Medical subject headings
- Macrophages
- Phagocytosis