Rapid Rebound of a Preexisting CXCR4-tropic Human Immunodeficiency Virus Variant After Allogeneic Transplantation With CCR5 Δ32 Homozygous Stem Cells.
case_report · Level V
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- Record sourced from PubMed, PMID 30020413.
- Also identified by DOI 10.1093/cid/ciy565.
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Abstract
Allogeneic stem cell transplantation (alloSCT) of homozygous CCR5 Δ32 stem cells once resulted in the cure of human immunodeficiency virus (HIV) infection. We have recently reported a viral breakthrough in a similar setting. Here, we demonstrate that the rapid rebound after alloSCT was related to a highly replicative CXCR4-tropic HIV variant, which could already be detected before alloSCT.
Medical subject headings
- HIV
- HIV Infections
- Stem Cell Transplantation
- Transplantation, Homologous
- Viral Load
- Viral Tropism