Repurposing an Old Drug for a New Epidemic: Ursodeoxycholic Acid to Prevent Recurrent Clostridioides difficile Infection.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 30020421.
- Also identified by DOI 10.1093/cid/ciy568.
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Abstract
Recurrent Clostridioides difficile infection (rCDI) may be mediated in part by secondary bile acids. Here we report salvage therapy with ursodeoxycholic acid (UDCA) to prevent rCDI in 16 high-risk patients. Patients on UDCA had a low observed recurrence rate (12.5%). Controlled trials are needed to confirm these observations.
Medical subject headings
- Anti-Bacterial Agents
- Cholagogues and Choleretics
- Clostridium Infections
- Drug Repositioning
- Secondary Prevention
- Ursodeoxycholic Acid