Impaired spatial memory codes in a mouse model of Rett syndrome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30028675.
- Also identified by DOI 10.7554/eLife.31451 and PMC identifier 6054527.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The <i>Mecp2<sup>+/-</sup></i> mouse model recapitulates many phenotypes of patients with Rett syndrome (RTT), including learning and memory deficits. It is unknown, however, how the disease state alters memory circuit functions in vivo in RTT mice. Here we recorded from hippocampal place cells, which are thought to encode spatial memories, in freely moving RTT mice and littermate controls. We found that place cells in RTT mice are impaired in their experience-dependent increase of spatial information. This impairment is accompanied by an enhanced baseline firing synchrony of place cells within ripple oscillations during rest, which consequently occludes the increase in synchrony after a novel experience. Behaviorally, contextual memory is normal at short but not long time scale in RTT mice. Our results suggest that hypersynchrony interferes with memory consolidation and leads to impaired spatial memory codes in RTT mice, providing a possible circuit mechanism for memory deficits in Rett Syndrome.
Medical subject headings
- Disease Models, Animal
- Memory Disorders
- Rett Syndrome
- Spatial Memory