Histidine metabolism boosts cancer therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30030511.
- Also identified by DOI 10.1038/d41586-018-05573-4 and PMC identifier 6445353.
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Abstract
Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.
Medical subject headings
- Histidine
- Neoplasms