Young blood for old kidneys? More questions than answers so far.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30031441.
- Also identified by DOI 10.1016/j.kint.2018.04.015.
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Abstract
The aging kidney has increased susceptibility to injury and decreased regenerative capacity. It is unknown if the effects of aging on acute kidney injury are reversible. In this issue, Liu et al., using a mouse heterochronic parabiosis ischemia-reperfusion model, demonstrate that a shared circulation between a young and older mouse results in decreased acute tubular injury. This study is an important first step using an interesting model, but many questions remain about how young blood reduces acute kidney injury in an older mouse.
Medical subject headings
- Kidney
- Reperfusion Injury