Somatic Cell Nuclear Transfer Reprogramming: Mechanisms and Applications.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30033121.
- Also identified by DOI 10.1016/j.stem.2018.06.018 and PMC identifier 6173619.
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Abstract
Successful cloning of monkeys, the first non-human primate species, by somatic cell nuclear transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken more than 20 years since the cloning of Dolly the sheep in 1997 to achieve this feat. This success was largely due to recent understanding of epigenetic barriers that impede SCNT-mediated reprogramming and the establishment of key methods to overcome these barriers, which also allowed efficient derivation of human pluripotent stem cells for cell therapy. Here, we summarize recent advances in SCNT technology and its potential applications for both reproductive and therapeutic cloning.
Medical subject headings
- Cellular Reprogramming
- Nuclear Transfer Techniques