An Overview of PET Radiochemistry, Part 1: The Covalent Labels <sup>18</sup>F, <sup>11</sup>C, and <sup>13</sup>N.
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- Record sourced from PubMed, PMID 30042159.
- Also identified by DOI 10.2967/jnumed.117.190793.
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Abstract
This continuing educational article introduces the radiochemistry of PET tracers that exhibit a covalently bound radiolabel with the nuclides <sup>11</sup>C, <sup>13</sup>N, and <sup>18</sup>F. The overall process of PET tracer production is explained, starting from the production of the radionuclide in a cyclotron; followed by the automatization process of the radiosynthesis, including the necessary steps for the respective synthesis; and finalized with the requirements for quality control.
Medical subject headings
- Carbon Radioisotopes
- Fluorine Radioisotopes
- Nitrogen Radioisotopes
- Positron-Emission Tomography
- Radiochemistry