Whirling Platelets Away for Transfusion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30053423.
- Also identified by DOI 10.1016/j.cell.2018.07.018 and PMC identifier 6487281.
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Abstract
With a growing demand for platelet transfusions, large-scale ex vivo platelet production would alleviate the reliance on donors. Now, Ito et al. report that turbulence is an important physical regulator of platelet generation in vivo and can be exploited in a bioreactor to enable clinical scale production of functional platelets starting from human iPSCs.
Medical subject headings
- Induced Pluripotent Stem Cells
- Platelet Transfusion