Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30061696.
- Also identified by DOI 10.1038/s41591-018-0132-5 and PMC identifier 6129204.
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Abstract
Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.
Medical subject headings
- Disease Progression
- Dysbiosis
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus