Controlled formation of chitosan particles by a clock reaction.
basic_science · Level V
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- Record sourced from PubMed, PMID 30062339.
- Also identified by DOI 10.1039/c8sm01060a.
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Abstract
Clock reactions allow precise control of chemical composition in the time domain. Such nonlinear chemical systems have recently been introduced to mimic the self-assembly pathways common in living organisms. Here, we demonstrate the use of a clock reaction to trigger the formation of polymeric nanoparticles. By adjusting the delay of a formaldehyde clock reaction, we controlled the precipitation of chitosan to form particles with sizes tunable in a wide range (from about 200 to 600 nm diameter). The chemical structure of chitosan was not significantly perturbed by the clock reagents.