Fat and Bone: PGC-1α Regulates Mesenchymal Cell Fate during Aging and Osteoporosis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30075123.
- Also identified by DOI 10.1016/j.stem.2018.07.010.
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Abstract
PGC-1α is a transcriptional co-activator associated with PPARγ that regulates thermogenic gene expression in brown fat. In this issue, Yu et al. (2018) show that PGC-1α regulates marrow mesenchymal stromal cell lineage allocation in vivo, inhibiting marrow adipogenesis and associated bone loss in the aging skeleton and following ovariectomy-induced osteoporosis.
Medical subject headings
- Mesenchymal Stem Cells
- Osteoporosis