Endoglin Targeting in Colorectal Tumor Microenvironment.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30076135.
- Also identified by DOI 10.1158/1078-0432.CCR-18-2023.
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Abstract
On endothelial cells, the TGFβ/BMP-9 coreceptor, endoglin, emerged as a promising antiangiogenic target in colorectal cancer. Its promiscuous expression by cancer-associated fibroblasts (CAF) emerges to facilitate metastasis. The multitarget impact of neutralizing endoglin may offer added benefit in controlling colorectal cancer.<i>See related article by Paauwe et al., p. 6331</i>.
Medical subject headings
- Cancer-Associated Fibroblasts
- Colorectal Neoplasms