Ebola Virus Shed Glycoprotein Triggers Differentiation, Infection, and Death of Monocytes Through Toll-Like Receptor 4 Activation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30085081.
- Also identified by DOI 10.1093/infdis/jiy406 and PMC identifier 6249564.
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Abstract
A better understanding of the mechanisms used by Ebola virus to disable the host immune system and spread the infection are of great importance for development of new therapeutic strategies. We demonstrate that treatment of monocytic cells with Ebola virus shed glycoprotein (GP) promotes their differentiation resulting in increased infection and cell death. The effects were inhibited by blocking Toll-like receptor 4 pathway. In addition, high levels of shed GP were detected in supernatants of cells treated with Ebola vaccines. This study highlights the role of shed GP in Ebola pathogenesis and also in adverse effects associated with Ebola vaccines.
Medical subject headings
- Cell Death
- Cell Differentiation
- Ebolavirus
- Glycoproteins
- Monocytes
- Toll-Like Receptor 4