A Mitochondrial Checkpoint in Autoimmune Disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30089238.
- Also identified by DOI 10.1016/j.cmet.2018.07.014 and PMC identifier 6487495.
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Abstract
Cell-fate decisions in innate and adaptive immune cells are metabolically regulated and modified by tissue-derived signals, thereby balancing protective and pathogenic immunity. Reporting in Science, Ling et al. (2018) have identified C1q as a mitochondrial activator that suppresses exuberant anti-self and anti-viral CD8 T cell effector responses to prevent autoimmune disease.
Medical subject headings
- Autoimmunity
- T-Lymphocytes