Translating In Vitro T Cell Metabolic Findings to In Vivo Tumor Models of Nutrient Competition.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30089240.
- Also identified by DOI 10.1016/j.cmet.2018.07.009 and PMC identifier 6463890.
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Abstract
Reductionist in vitro T cell assays have identified metabolic pathways critical for T cell function within the tumor microenvironment. We discuss the challenges of testing these concepts using in vivo tumor models.
Medical subject headings
- Metabolic Networks and Pathways
- Neoplasms
- T-Lymphocytes
- Tumor Microenvironment