Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30096309.
- Also identified by DOI 10.1016/j.cell.2018.07.030.
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Abstract
Krebs cycle intermediates traditionally link to oxidative phosphorylation whilst also making key cell components. It is now clear that some of these metabolites also act as signals. Succinate plays an important role in inflammatory, hypoxic, and metabolic signaling, while itaconate (from another Krebs cycle intermediate, cis-aconitate) has an anti-inflammatory role.
Medical subject headings
- Citric Acid Cycle
- Succinates
- Succinic Acid