CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 30100574.
- Also identified by DOI 10.1136/thoraxjnl-2018-211931.
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Abstract
Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (β=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (β=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction. TRIAL REGISTRATION NUMBER: Clinical trial registered with the Dutch trial register www.trialregister.nl (NTR2876), Results.
Medical subject headings
- Airway Remodeling
- Bronchoscopy
- Muscle, Skeletal
- Pneumonectomy
- Pulmonary Emphysema