A Single-Nucleotide Polymorphism Upstream of the HLA-C Locus Is Associated With an Anti-Hepatitis C Virus-Seronegative State in a High-Risk Exposed Cohort.
case_control · Level III
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- Record sourced from PubMed, PMID 30102364.
- Also identified by DOI 10.1093/infdis/jiy492.
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Abstract
In this study, we examined the impact of the rs9264942 single-nucleotide polymorphism, previously shown to be associated with human immunodeficiency virus infection status and HLA-C expression, on the hepatitis C virus status in 359 people who inject drugs (PWID). The linkage of rs9264942 alleles to HLA-C antigens assigned to different expression levels was confirmed. Multivariate analysis revealed the age (P = .003) and the rs9264942 genotype (P = .006) to be independent factors for the classification to the PWID groups. Our study showed that the presence of the rs9264942 C/C genotype was associated with persistent seronegativity.
Medical subject headings
- Antibodies, Viral
- Genetic Predisposition to Disease
- HLA-C Antigens
- Hepatitis C
- Polymorphism, Single Nucleotide