Resolution of chronic inflammatory disease: universal and tissue-specific concepts.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30111884.
- Also identified by DOI 10.1038/s41467-018-05800-6 and PMC identifier 6093916.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Inflammation and its resolution is under-studied in medicine despite being essential for understanding the development of chronic inflammatory disease. In this review article, we discuss the resolution of inflammation in both a biological and translational context. We introduce the concept of impaired resolution leading to diseases like rheumatoid arthritis, Crohn's disease, and asthma, as well as the cellular and molecular components that contribute to resolution of joint, gut, and lung inflammation, respectively. Finally, we discuss potential intervention strategies for fostering the resolution process, and their implications for the therapy of inflammatory diseases.
Medical subject headings
- Arthritis, Rheumatoid
- Asthma
- Crohn Disease
- Inflammation