Intron retention is a source of neoepitopes in cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30114007.
- Also identified by DOI 10.1038/nbt.4239 and PMC identifier 6226333.
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Abstract
We present an in silico approach to identifying neoepitopes derived from intron retention events in tumor transcriptomes. Using mass spectrometry immunopeptidome analysis, we show that retained intron neoepitopes are processed and presented on MHC I on the surface of cancer cell lines. RNA-derived neoepitopes should be considered for prospective personalized cancer vaccine development.
Medical subject headings
- Computer Simulation
- Epitopes
- Introns
- Models, Genetic
- Neoplasms