Rapid and efficient induction of functional astrocytes from human pluripotent stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30127505.
- Also identified by DOI 10.1038/s41592-018-0103-2.
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Abstract
The derivation of astrocytes from human pluripotent stem cells is currently slow and inefficient. We demonstrate that overexpression of the transcription factors SOX9 and NFIB in human pluripotent stem cells rapidly and efficiently yields homogeneous populations of induced astrocytes. In our study these cells exhibited molecular and functional properties resembling those of adult human astrocytes and were deemed suitable for disease modeling. Our method provides new possibilities for the study of human astrocytes in health and disease.
Medical subject headings
- Astrocytes
- Cell Differentiation
- Pluripotent Stem Cells
- SOX9 Transcription Factor