Genomic and epidemiological monitoring of yellow fever virus transmission potential.
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Where this comes from
- Record sourced from PubMed, PMID 30139911.
- Also identified by DOI 10.1126/science.aat7115 and PMC identifier 6874500.
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Abstract
The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian <i>Aedes</i> species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.
Medical subject headings
- Disease Outbreaks
- Epidemiological Monitoring
- Genomics
- Yellow Fever
- Yellow fever virus