PP1 Phosphatase Complexes: Undruggable No Longer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30142342.
- Also identified by DOI 10.1016/j.cell.2018.08.007.
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Abstract
The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.
Medical subject headings
- Animals
- Mice
- Phosphorylation
- Protein Phosphatase 1