Automated O<sub>2</sub> titration improves exercise capacity in patients with hypercapnic chronic obstructive pulmonary disease: a randomised controlled cross-over trial.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 30166425.
- Also identified by DOI 10.1136/thoraxjnl-2018-211967.
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Abstract
Automatically titrated O<sub>2</sub> flows (FreeO<sub>2</sub>) was compared with constant O<sub>2</sub> flow on exercise capacity, O<sub>2</sub> saturation and risk of hyperoxia-related hypercapnia in patients with severe COPD with baseline hypercapnia and long-term oxygen therapy (LTOT). Twelve patients were enrolled in a randomised double-blind cross-over study to perform exercise with either FreeO<sub>2</sub> or constant flow. Endurance time (primary outcome) and SpO<sub>2</sub> were both significantly improved with FreeO<sub>2</sub>compared with constant flow (p<0.04), although pCO<sub>2</sub> was similar in both conditions. Automated titration of O<sub>2</sub> significantly and clinically improved endurance walking time in patients with severe COPD receiving LTOT, without worsening of pCO<sub>2</sub> TRIAL REGISTRATION NUMBER: Results , NCT01575327.
Medical subject headings
- Exercise Tolerance
- Hypercapnia
- Oxygen Inhalation Therapy
- Pulmonary Disease, Chronic Obstructive