Emerging applications for DNA writers and molecular recorders.
review · Level V
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- Record sourced from PubMed, PMID 30166483.
- Also identified by DOI 10.1126/science.aat9249 and PMC identifier 6995688.
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Abstract
Natural life is encoded by evolvable, DNA-based memory. Recent advances in dynamic genome-engineering technologies, which we collectively refer to as in vivo DNA writing, have opened new avenues for investigating and engineering biology. This Review surveys these technological advances, outlines their prospects and emerging applications, and discusses the features and current limitations of these technologies for building various genetic circuits for processing and recording information in living cells.
Medical subject headings
- Gene Editing
- Genetic Engineering
- Information Storage and Retrieval