Coated microneedle-based cutaneous immunotherapy prevents Der p 1-induced airway allergy in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30171871.
- Also identified by DOI 10.1016/j.jaci.2018.08.017 and PMC identifier 6353555.
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Abstract
Der p1-coated microneedles after just three minutes of application led to efficient allergen delivery into skin and prevented development of airway allergy in a mouse. Allergen-coated microneedles may have potential for minimally-invasive allergen vaccination and immunotherapy.
Medical subject headings
- Allergens
- Antigens, Dermatophagoides
- Arthropod Proteins
- Cysteine Endopeptidases
- Desensitization, Immunologic
- Respiratory Hypersensitivity