In vivo detection of optically-evoked opioid peptide release.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30175957.
- Also identified by DOI 10.7554/eLife.36520 and PMC identifier 6135606.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to adequately dissect endogenous peptide release in vivo. To this end we developed a system that combines in vivo optogenetics with microdialysis and a highly sensitive mass spectrometry-based assay to measure opioid peptide release in freely moving rodents.
Medical subject headings
- Brain
- Opioid Peptides
- Optogenetics