X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30177374.
- Also identified by DOI 10.1016/j.radonc.2018.08.016.
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Abstract
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with synchrotron generated X-rays does not induce memory deficit; it reduces hippocampal cell-division impairment and induces less reactive astrogliosis.
Medical subject headings
- Brain Injuries
- Cranial Irradiation
- Radiation Injuries, Experimental
- Synchrotrons