Encoding canonical DNA quadruplex structure.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30182059.
- Also identified by DOI 10.1126/sciadv.aat3007 and PMC identifier 6118410.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The main challenge in DNA quadruplex design is to encode a three-dimensional structure into the primary sequence, despite its multiple, repetitive guanine segments. We identify and detail structural elements describing all 14 feasible canonical quadruplex scaffolds and demonstrate their use in control of design. This work outlines a new roadmap for implementation of targeted design of quadruplexes for material, biotechnological, and therapeutic applications.
Medical subject headings
- G-Quadruplexes
- Guanine
- Molecular Dynamics Simulation
- Nucleic Acid Conformation