A Mitochondrial-Derived Peptide Exercises the Nuclear Option.
Where this comes from
- Record sourced from PubMed, PMID 30184481.
- Also identified by DOI 10.1016/j.cmet.2018.08.017.
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Abstract
The vast majority of mitochondrial proteins are encoded by nuclear genes, giving the nucleus ultimate control of mitochondrial biogenesis, dynamics, and function. However, in this issue Kim et al. (2018) demonstrate a reversal of fortune, whereby an mtDNA-encoded peptide, MOTS-c, is targeted to the nucleus to signal changes in gene expression.
Medical subject headings
- Cell Nucleus
- Mitochondria