T Cell Metabolism Has Evolved to Tolerate Tuberculosis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 30184482.
- Also identified by DOI 10.1016/j.cmet.2018.08.015.
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Abstract
Although T cells are important in preventing tuberculosis progression, their role in disease tolerance is unknown. Recently in Science Immunology, Tzelepis et al. (2018) have revealed that mitochondrial cyclophilin D controls T cell metabolism and proliferation, contributing to tolerance. Cyclophilin D loss leads to immunopathology and increased mortality, without impacting bacterial burden.
Medical subject headings
- T-Lymphocytes
- Tuberculosis