Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30193106.
- Also identified by DOI 10.1016/j.cell.2018.08.035.
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Abstract
Partial loss of TANK-binding kinase 1 (TBK1) causes amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Xu et al. identify the role of TBK1 in suppressing neuroinflammation and apoptosis by its inhibition of the receptor-interacting serine/threonine-protein kinase 1 (RIPK1) and elucidate how aging and genetic susceptibility together cause neuroinflammation.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Frontotemporal Dementia