Metabolic Frugality Marks Cancer Cells for Immune Targeting.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30193108.
- Also identified by DOI 10.1016/j.cell.2018.08.023.
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Abstract
Altered cell metabolism is ubiquitous in cancer cells; however, it remains challenging to exploit these alterations for cancer therapy. A new study reveals that metabolic alterations to the urea cycle promote tumor growth but unexpectedly also trigger mutations that mark cancer cells for recognition by immunotherapy.
Medical subject headings
- Immunotherapy
- Neoplasms