The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 30193109.
- Also identified by DOI 10.1016/j.cell.2018.08.027 and PMC identifier 6136429.
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Abstract
Chromosomal instability (CIN) is a hallmark of human cancer, and it is associated with poor prognosis, metastasis, and therapeutic resistance. CIN results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. In addition to generating genomic heterogeneity that acts as a substrate for natural selection, CIN promotes inflammatory signaling by introducing double-stranded DNA into the cytosol, engaging the cGAS-STING anti-viral pathway. These multipronged effects distinguish CIN as a central driver of tumor evolution and as a genomic source for the crosstalk between the tumor and its microenvironment, in the course of immune editing and evasion.
Medical subject headings
- Chromosomal Instability