An Unexpected Calm: Mfge8 Controls Stem Cell Quiescence and Maintenance.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 30193126.
- Also identified by DOI 10.1016/j.stem.2018.08.006.
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Abstract
Radial glia-like neural stem cells (RGLs) in the mouse hippocampus generate neurons throughout life, but RGL maintenance mechanisms remain unclear. In this issue of Cell Stem Cell, Zhou et al. (2018) identified Mfge8, a well-known mediator of the "eat-me" signal, as a factor that reinforces quiescence and protects the RGL niche from depletion.
Medical subject headings
- Adult Stem Cells
- Neural Stem Cells