Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis.
meta_analysis · Level I
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- Record sourced from PubMed, PMID 30202144.
- Also identified by DOI 10.1016/j.jor.2018.08.033 and PMC identifier 6128174.
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Abstract
To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted. A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018. The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques. The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.
Anatomy
- knee