A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30203722.
- Also identified by DOI 10.1089/ten.TEA.2018.0142 and PMC identifier 6482911.
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Abstract
The synovium envelops the diarthrodial joint and plays a key regulatory role in defining the composition of the synovial fluid through filtration and biosynthesis of critical boundary lubricants. Synovium changes often precede cartilage damage in osteoarthritis. We describe a novel <i>in vitro</i> tissue engineered model, validated against native synovium explants, to investigate the structure-function of synovium through quantitative solute transport measures. Synovium was evaluated in the presence of a proinflammatory cytokine, interleukin-1, or the clinically relevant corticosteroid, dexamethasone. We anticipate that a better understanding of synovium transport would support efforts to develop more effective strategies aimed at restoring joint health.
Medical subject headings
- Osteoarthritis
- Synovial Membrane
- Tissue Engineering