Structural mechanism of Myb-MuvB assembly.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 30224471.
- Also identified by DOI 10.1073/pnas.1808136115 and PMC identifier 6176624.
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Abstract
The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2 and M phases of the cell cycle. We have identified the domain in B-Myb that is essential for the assembly of the Myb-MuvB (MMB) complex. We determined a crystal structure that reveals how this B-Myb domain binds MuvB through the adaptor protein LIN52 and the scaffold protein LIN9. The structure and biochemical analysis provide an understanding of how oncogenic B-Myb is recruited to regulate genes required for cell-cycle progression, and the MMB interface presents a potential therapeutic target to inhibit cancer cell proliferation.
Medical subject headings
- Cell Cycle
- Cell Cycle Proteins
- Multiprotein Complexes
- Neoplasm Proteins
- Neoplasms
- Nuclear Proteins
- Trans-Activators
- Tumor Suppressor Proteins