Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types.
Where this comes from
- Record sourced from PubMed, PMID 30234181.
- Also identified by DOI 10.1200/PO.17.00286 and PMC identifier 6139373.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The prevalence of homologous recombination DNA damage repair (HR-DDR) deficiencies among all tumor lineages is not well characterized. Therapy directed toward homologous recombination DDR deficiency (HRD) is now approved in ovarian and breast cancer, and there may be additional opportunities for benefit for patients with other cancers. Comprehensive evaluations for HRD are limited in part by the lack of a uniform, cost-effective method for testing and defining HRD. Molecular profiles of 52,426 tumors were reviewed to identify pathogenic mutations in the HR-DDR genes <i>ARID1A</i>, <i>ATM</i>, <i>ATRX</i>, <i>BAP1</i>, <i>BARD1</i>, <i>BLM</i>, <i>BRCA1/2</i>, <i>BRIP1</i>, <i>CHEK1/2</i>, <i>FANCA/C/D2/E/F/G/L</i>, <i>MRE11A</i>, <i>NBN</i>, <i>PALB2</i>, <i>RAD50</i>, <i>RAD51</i>, <i>RAD51B</i>, or <i>WRN</i>. From solid tumors submitted to Caris Life Sciences, molecular profiles were generated using next-generation sequencing (NGS; average read depth, 500×). A total of 17,566 tumors were sequenced with NGS600 (n = 592 genes), and 34,860 tumors underwent hotspot Illumina MiSeq platform testing (n = 47 genes). Of the tumors that underwent NGS600 testing, the overall frequency of HRDDR mutations detected was 17.4%, and the most commonly mutated lineages were endometrial (34.4%; n = 1,475), biliary tract (28.9%; n = 343), bladder (23.9%; n = 201), hepatocellular (20.9%; n = 115), gastroesophageal (20.8%; n = 619), and ovarian (20.0%; n = 2,489). Least commonly mutated lineages included GI stromal (3.7%; n = 108), head and neck (6.8%; n = 206), and sarcoma (9.3%; n = 592). <i>ARID1A</i> was the most commonly mutated gene (7.2%), followed by <i>BRCA2</i> (3.0%), <i>BRCA1</i> (2.8%), <i>ATM</i> (1.3%), <i>ATRX</i> (1.3%), and <i>CHEK2</i> (1.3%). HR-DDR mutations were seen in 17.4% of tumors across 21 cancer lineages, providing a path to explore the role of HRD-directed therapies, including poly-ADP ribose polymerase inhibitors, DNA-damaging chemotherapies, and newer agents such as ATR inhibitors.